Top Kratom Potentiators

• Substances that have benefits, but do not influence the strength of Kratom:
  • Turmeric and black pepper, lemon or vinegar, ginger, grapefruit, and honey
• Potentiators for Kratom:
  • Caffeine (preferably black tea), St. john’s wort, Valerian, hawthorn, white mistletoe, and wormwood
• Herbs that may also work:
  • Damiana and blue lotus
• Grapefruit juice is recommended as it inhibits the enzyme CYP3A4, elonging the duration of Kratom’s effects
• Citric acid works immediately to help to ‘digest’ part of the Kratom to allow for more to hit the bloodstream at once. Freezing Kratom tea until the red bubble appears is a mile stronger because it helps break down the cell walls
• Grapefruit can interact with medications; high in vitamin C and low in fructose, but it can increase plasma concentrations of several different drugs

• Kratom enthusiasts use various substances to “potentiate” kratom’s effects like grapefruit juice, turmeric (curcumin), black pepper (piperine/Bioperine), Moringa oleifera, Agmatine, L tyrosine, CBD, and any drink with citric acid.
  • Mitragyna javanica, Mitragyna hirsuta, Uncaria tomentosa (Cat’s Claw), and Picralima nitida (Akuamma) are also used to extend the duration of effects and increase efficacy.
  • Rhodiola rosea, Gotu Kola, Bacopa monnieri, Ginkgo Biloba, Ashwagandha, Mucuna pruriens, Chamomile, Skullcap, Lemon Balm, Kava, functional mushrooms, and Panax Ginseng are other herbal supplements and adaptogens that can increase the beneficial effects
• Freezing kratom powder and then preparing it using the “Red Bubble” method increases potency 2-3 fold depending on the quality of your powder and the specific strain. This allows you to use smaller doses of kratom without decreasing the level of efficacy that you’re used to
  • Red Bubble Tek Kratom - mixes water, lemon juice, apple cider vinegar, black pepper, and fresh boiled water. Let cool 20min then put in freezer overnight or 8 or so hrs.
• Some users have tried relatively unknown supplements like 2-DCK (10 x more powerful than Agmatine) and Magnesium bis glycinate, Vitamin D, and NAC which are best for tolerance issues, reduce anxiolytic, antidepressant, antipsychotic, stimulant, and cognitive function
• Drink BaiCalm caps that have Curcumin and Piperine which supposedly helps potentiate kratom and the other stuff in it synergizes well with kratom
• Some Reddit members warn that grapefruit juice can be potentially life-threatening depending on what you take as it affects the metabolization of a lot of prescription drugs.

• Top Kratom Potentiators
  • User’s anecdote: taking low doses, on empty stomach, with coffee after tea
  • User’s anecdote: chewing lemon slices with dosing
  • User’s anecdote: drinking Kratom with lemon/lime, or orange juice helps prolong effects
  • User’s comment: milk made Kratom weaker (could be pH-dependent)
  • User’s comment: all other potentiators are placebo
  • User’s comment: dosing shouldn’t exceed 1.4g
  • User’s anecdote: mixing Kratom with turmeric helps boost energy (but one user doesn’t notice a difference)
    • User’s comment: black pepper (piperine) inhibits metabolic conversion of mitragynine to 7-hydroxymitragynine (a more potent alkaloid), so turmeric only may be better
    • User’s anecdote: taking Kratom with straight turmeric powder, with hot decaf coffee and water helps inflammation and lengthens the Kratom experience
      • User’s tips: build up over time, be consistent, use an amount in a range where it doesn’t cause heartburn or reflux
  • User’s comment: taking Kratom with food/full stomach results in cleaner effects with less fatigue.

• Kratom potentiators:
  • Turmeric with black pepper extract
  • L tyrosine
  • Agmatine
  • Acidic juice (OJ or grapefruit juice) before doses
  • Grapefruit juice with morning dose
  • Cayenne pepper
  • V8 with Tabasco Sauce + Kratom
  • Washing with grapefruit juice or orange juice
  • Black seed oil
  • Lime juice concentrate or lemon juice concentrate with a few spoons of sugar and water to taste
  • Phenibut in the morning just before taking Kratom
  • Lemon water with a dash of cayenne
  • Cinnamon increases metabolism rate
  • Exercise and sunshine
• Comments:
  • Turmeric, pepper, and agmatine don’t help in noticeable ways, but may help with tolerance
  • Black pepper should be powderized with a mortar and pestle for less nausea and better effects
  • Some people have to take turmeric with black pepper every day for a couple of weeks or longer before noticing benefits
  • Kava synergy with Kratom is phenomenal
  • Some users had bad experiences with agmatine sulfate (toxic selenium in their blood)

• Top Kratom Potentiators:
  • Potentiators amplify the potency of Kratom
  • Organic substances like apple cider vinegar, turmeric, and black pepper are Kratom potentiators
  • Turmeric is best used before Kratom dose, whereas others like apple cider vinegar do not require a set schedule
  • Citrus juice, like grapefruit or lemon juice, is a Kratom potentiator
  • Start small and work your way up if using Kratom potentiators.

💭  Looking into

Are there any other substances that can be used to potentiate Kratom?

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What are the potential risks associated with taking Kratom potentiators?

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What are the effects of acidic drinks on Kratom potency?

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What are the benefits of taking Kratom with honey?

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What is the effect of black pepper on Kratom potency?

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What is the optimal dosage of turmeric to be taken with Kratom?

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What is the scientific basis for the use of grapefruit juice as a Kratom potentiator?

• Top 13 Kratom Potentiators reviewed on Reddit 2 years ago
  • Segment 1: brief discussion on science supporting open access
  • Segment 2: actual potentiators
    • Acids
    • Fats
    • Black Pepper/Cayenne
    • Curcumin
    • BSO
    • Mag
    • Agmatine
    • Caffeine
    • Cat’Claw
    • Tyrosine/DLPA/Mucuna Pruriens
    • Akuamma
    • L-Theanine
    • The Acid-Freeze Tek
  • Some Reddit users
    • Recommend adding lemon juice
    • Use McCormick’s lemon extract and red wine vinegar for powerful extract
    • Suggest using lecithin to encapsulate kratom in liposomes
    • Use liquid sunflower lecithin for better mixing
    • Mix kratom in protein shake with lecithin for strong effects
    • Suggest magnesium-citrate and malate as effective acid sources
    • Grapefruit juice recommended but excessive sugar consumption not advised
    • DXM and GFJ combo for recreational use
• None

• Top 10 Best Kratom Potentiators:

  • #1 GABA Brain Food: supplement to enhance relaxation effects; contains L-Citrulline, Rosmarinic acid, Grape seed extract.

  • #2 Agmatine: metabolite of essential amino acid L-arginine; reduces inflammation, lowers tolerance, and enhances pain relief.

  • #3 Akuamma Seed: from tropical trees, has alkaloid akuammine which produces longer-lasting effects as it binds to the same opioid receptors as kratom.

  • #4 Grapefruit: stimulates metabolism of kratom, making alkaloids more efficient and stronger for up to 10 hours.

  • #5 Turmeric: polyphenol which enhances absorption of kratom alkaloids and decreases side effects like nausea.

  • #6 DLPA: amino acid for pain relief and improvement of mood; increases dopamine and norepinephrine levels in the brain to enhance kratom alkaloids for longer pain relief experiences.

  • #7 Cayenne Pepper: contains capsaicin, which increases absorption rates of kratom alkaloids and provides analgesic properties.

  • #8 Cat’s Claw: herb that boosts immune system, anti-inflammatory properties, improves kratom absorption in the liver, and increases bioavailability.

  • #9 Lemon Balm: mild sedating herb that calms down brain activity for restful sleep and increases absorption of kratom alkaloids to make sedative effects stronger.

  • #10 CBD: non-psychoactive ingredient in cannabis that can be used for pain management, fibromyalgia, depression, and anxiety.

• 2 Enzymes that enhance bioavailability:

  • Pancreatin: supplement mixture of enzymes used to break down food and treat digestive problems and malabsorption.

  • Papaya Enzymes: contains enzymes to aid in digestion and stabilize blood sugar levels.

• Conclusion: Experiment with different potentiators to find the one that works best, but spicy food, grapefruit, and turmeric, are generally reported to be effective. Agmatine is best for enhancing pain relief.

• Potentiators to Reduce Kratom Tolerance

  • NMDA antagonists like ketamine help mitigate tolerance
  • Other potentiators can increase tolerance by keeping alkaloids in nervous system longer

• Potentiators to Increase Kratom Duration

  • Most potentiators increase effects of kratom
  • CYP inhibitors are better for increasing duration

• Potentiators to Save Money

  • Potentiation can decrease amount of kratom used by close to half

• Potentiators to Prevent Withdrawal, Addiction, & Side Effects

  • Potentiators can help manage or prevent addiction to kratom
  • Certain potentiators allow smaller doses and same effect to help wean off kratom
  • NMDA antagonists can prevent or relieve withdrawal symptoms
  • Potentiators can reduce side effects of kratom

• Examples of Kratom Potentiators

  • DXM (Dextromethorphan)
    • Small doses of DXM can help with NMDA antagonism for tolerance and potentiation
  • Other NMDA antagonists
    • Ketamine: can prevent tolerance and fight withdrawal symptoms
    • Memantine: long-lasting NMDA antagonist that prevents buildup of tolerance
    • Magnesium: acts as a mild NMDA antagonist and helps keep tolerance at bay
  • Naltrexone (Opioid Antagonists)
    • Low doses of naltrexone can potentiate and reduce tolerance
  • Cytochrome Inhibitors
    • CYP2C9 enzyme: kratom is potent inhibitor, affects anesthetics, painkillers, cannabinoids, and many other substances
    • CYP2D6 enzyme: kratom is potent inhibitor, used by most pharmaceuticals, opioids, and even kratom itself
    • CBD: potent inhibitor of CYP450
    • Grapefruit Juice: potent cytochrome inhibitor
    • Watercress: inhibitor of CYP450
    • Turmeric: contains a compound that inhibits CYP2D6

• “The BEST kratom potentiator!”
  • A post from 2 years ago on r/kratom with 39 points
  • OP suggests mixing a cup of grapefruit juice with magnesium powder, cayenne pepper, and 500mg agmatine sulfate
  • Some comment suggestions:
    • Ginger for constipation
    • Lemon/lime/orange juice
    • Drinking 32oz of water within 5min of dose
    • 2 shots of whiskey
    • Turmeric and black pepper in tea
    • 30mg dxm
    • Magnesium citrate for constipation
    • Movement/activity
    • Agmatine to potentiate other substances
    • Heroin
    • Phenibut (caution advised)
    • Substances that work on GABA receptors
    • Turmeric with black pepper
    • Adding benzos to kratom
• Some users advise less is more
• Water and staying hydrated appears to be a common theme None

• Top Potentiators for Kratom
  • Grapefruit juice.
    • Drinking grapefruit juice two hours before consuming kratom.
    • Some users argue that it does not help with Kratom and might decrease its effectiveness.
  • Turmeric.
    • Adding turmeric to Kratom tea or consuming turmeric capsules.
    • Mixing five to ten grams of Kratom, a tablespoon or two of turmeric and a teaspoon or two of ground pepper for tea.
  • Black pepper.
  • Raw Honey.
    • Taking Kratom with honey.
    • Honey serves as a vehicle for anything added to it.
  • Lemonade or orange juice.
    • Anything acidic, such as citrus drinks.
  • Coffee.
    • Drinking coffee after consuming Kratom.
    • Coffee makes Kratom more effective for some users.
  • Cayenne pepper.
  • Agmatine sulfate.
    • Taking agmatine sulfate half an hour before consuming Kratom.
    • Prolongs effects and pain relief during tapering.
    • Mutes the mood euphoria effects of Kratom for many.
  • None.

💭  Looking into

What are the best Kratom potentiators?